Basic Information
VIS ID
TVIS10010123
Fusion event
HBV-NEXMIF integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1863
Orient
+
Integrated sequence
AGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACT| |GTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTT
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
11607951/11586404 (Hg38)
End
11607951/11586404 (Hg38)
Orient
-
Location type
Intronic
Target gene
NEXMIF
miRNAs that regulate target gene
hsa-mir-5580-3p ; hsa-mir-382-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-5011-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3133 ; hsa-mir-642a-5p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-216b-3p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-600 ; hsa-mir-6769a-3p ; hsa-mir-3943 ; hsa-mir-4323
Nearest miRNA
hsa-mir-210/Upstream/1078078; hsa-let-7a-2/Downstream/70247;
Nearest TSS
ENST00000527297/Upstream/16320; ENST00000525257/Downstream/35354;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/654879, chr11-CpG: 149/Downstream/34170
Upstream sequence
tattttgaaattttctcagtttaaatttctattgtggcaaatattaactgatacaacctatagcaacaaaactcccttggggttttcaataatttttaca
Downstream sequence
agcataaaggagtcctaagaccaaaaagtttgaaaacttctgGCTTAAACTATAGCTAAAAGATAGGAAATTCTACCTGTTCAGGGCCCAGCATCCATAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate