VISDB Viral Integration Site DataBase

VIS ID

TVIS10010124

Fusion event

HBV-APOC3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1827

Orient

-

Integrated sequence

AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT

Chromosome

chr11

Cytoband

q23.3

Reference genome

Start

End

116701929/116831213 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA11G ; FRA11B

Target gene

miRNAs that regulate target gene

hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-6729-5p ; hsa-mir-4649-5p ; hsa-mir-661 ; hsa-mir-4696 ; hsa-mir-4486 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-4267 ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-451b ; hsa-mir-508-5p ; hsa-mir-4432 ; hsa-mir-6818-3p ; hsa-mir-548s ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-4684-5p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-3926 ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-3613-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-34a-3p ; hsa-mir-6732-3p ; hsa-mir-5583-3p ; hsa-mir-548c-3p ; hsa-mir-4271 ; hsa-mir-1273g-3p ; hsa-mir-4252

Nearest miRNA

hsa-mir-10392/Upstream/3381125; hsa-let-7a-2/Downstream/1812787;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/9569, chr11-CpG: 48/Downstream/4552

Upstream sequence

CCCGGAGCAGTCCTAGGGCGTGCCGTTTTAGCCCTCATTTCCATTTTCCTTTCCTTTCCctttctttctctttctatttctttctttctttctttctttc

Downstream sequence

tttctttctttctttctttctttctttctttctttctttctttcctttctttctttcctttctttctttcctttctttctttctttcctttctttctctt