VISDB Viral Integration Site DataBase

VIS ID

TVIS10010133

Fusion event

HBV-ACACB integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1780

Orient

+

Integrated sequence

AATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGA| |GGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCT

Chromosome

chr12

Cytoband

q24.11

Reference genome

Start

End

109569791/109131986 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-148b-3p ; hsa-mir-544a ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4252 ; hsa-mir-6797-3p ; hsa-mir-6076 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-425-5p ; hsa-mir-596 ; hsa-mir-508-5p

Nearest miRNA

hsa-let-7i/Upstream/294980; hsa-mir-1178/Downstream/701362;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/20617, chr12-CpG: 34/Downstream/22524

Nearby gene

UNG(-20993) ; ACACB(+7411) ;

Upstream sequence

TCTTGACCACGGCCCCCCCACGCCACCGTCTGGCACCGTTAGTTTGCATGTCGATCTGCGGCTGTGTCTTAAAGGTACACAGCCAGGTGTCTGTCTGTTT

Downstream sequence

TTAGGATCATATCTACGCACTCCTTGTACCACCTGCTGCCTTATGGAATTTACTTATCTCCACTGCAGTGGTGGGACAGTGGAAAAGGTATGAGCAAGGG