Basic Information
VIS ID
TVIS10010135
Fusion event
HBV-LINC01257 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1815
Orient
-
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
131696334/131211789 (Hg38)
End
131696334/131211789 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA12E
Target gene
LINC01257
Nearest miRNA
hsa-let-7i/Upstream/2917611; hsa-mir-6763/Downstream/1370208;
Nearest TSS
ENST00000382841/Upstream/4582; ENST00000428272/Downstream/86183;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/46726, chr12-CpG: 108/Downstream/86759
Upstream sequence
GGGAATTAACCATAACTTTAAGAAAATACATTCATTCTGCCTTGCAGGGGGTGCAGAAAGGGCACTGGGGTACTTGGGCTGTGGGGACCACGTCAGCTTC
Downstream sequence
TAGCCCCGCTCTAGGATGTGGAAGTCTCTGgagaagggtgggaaaataccccaggtcctccctggccccatcgcccaccagggcctctcgctgtctcaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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