Basic Information
VIS ID
TVIS10010136
Fusion event
HBV-LINC01257 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2212
Orient
+
Integrated sequence
TGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTC| |ACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGC
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
131697102/131212557 (Hg38)
End
131697102/131212557 (Hg38)
Orient
-
Location type
ncRNA_exonic
Fragile sites / regions
FRA12E
Target gene
LINC01257
Nearest miRNA
hsa-let-7i/Upstream/2918379; hsa-mir-6763/Downstream/1369440;
Nearest TSS
ENST00000382841/Upstream/5350; ENST00000428272/Downstream/85415;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/47494, chr12-CpG: 108/Downstream/85991
Upstream sequence
caaccacaggaaaaaaaatacataaattgaatttcatcaaaatttaaaacttttgtgcattaaagttcatgatcaaaaaagcgagaagaaaacccagaga
Downstream sequence
atgagtgaaatatttgcaaatcatacatctgggacaagtatccagaatatataaaaattcttagaactcaacaatataaagaaaaataaccaaattaaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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