Basic Information
VIS ID
TVIS10010141
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2191
Orient
+
Integrated sequence
GAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGT| |TCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCC
Host Sequence
Chromosome
chr12
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
61607486/61213705 (Hg38)
End
61607486/61213705 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1228/Upstream/3389013; hsa-let-7i/Downstream/1046654;
Nearest TSS
ENST00000382841/Upstream/1120841; ENST00000546718/Downstream/613528;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1616979, chr12-CpG: 117/Downstream/977282
Nearby gene
SLC16A7(-1423851) ; TAFA2(+494543) ;
Upstream sequence
ACTACTCCTTTAACTCTTCCTGACTTTTTATGTTATTTTTTTTTTTTTTTGCCTGTACCTTTATACCTAACTAAATATTTCATTTCCTTCCTTATAACCT
Downstream sequence
GTCtatcttggtccgttcgggctgctataacaaaataacatagcctaggccgcttataaacaatagaaatttttgtctcacagttctgcaacctgagaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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