Basic Information
VIS ID
TVIS10010143
Fusion event
HBV-LOC105369878 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2457
Orient
+
Integrated sequence
AGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTAT| |TCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACAT
Host Sequence
Chromosome
chr12
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
87543614/87149837 (Hg38)
End
87543614/87149837 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
LOC105369878
Nearest miRNA
hsa-let-7i/Upstream/404688; hsa-mir-1178/Downstream/7411952;
Nearest TSS
ENST00000382841/Upstream/310839; ENST00000551280/Downstream/645896;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1868915, chr12-CpG: 52/Downstream/885491
Nearby gene
MGAT4C(-310933) ; MKRN9P(+633049) ;
Upstream sequence
aacttgtatttttgttttatggggcctttgtgatttatgctttaaaaaggttctgatttgatgtgtttccaggatttgtttcatgatttagagctccttt
Downstream sequence
taacagttttcatagtgatggctttgtaatggtgaattctcttagcatttgtttgtctgaaaacgactgtatctttccttcaaatatgatgcttagtttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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