Basic Information
VIS ID
TVIS10010148
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1764
Orient
-
Integrated sequence
CTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAA| |GGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTG
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
80764086/80189951 (Hg38)
End
80764086/80189951 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/2491835; hsa-mir-1267/Downstream/7428714;
Nearest TSS
ENST00000623511/Upstream/178874; ENST00000456588/Downstream/149708;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/708373, chr13-CpG: 23/Downstream/149071
Nearby gene
NDFIP2(-633874) ; SPRY2(+146026) ;
Nearest cancer related gene
SPRY2(OG, +146026) ;
Upstream sequence
aacggccccacccctatctcccttcactgactctcttttcagactcagcccacctgcacccaggtgattaaaagctttattgctcgcacaaagcctgttt
Downstream sequence
ggtggtctcttaatacgggcgcgcgtgaaacccaggaggcagaggttgcagcgaatttatattgcaccactgcactccagcctgtgcaacaagagtgaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate