Basic Information
VIS ID
TVIS10010149
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
82272272/81698137 (Hg38)
End
82272272/81698137 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/4000021; hsa-mir-1267/Downstream/5920528;
Nearest TSS
ENST00000623511/Upstream/447699; ENST00000446314/Downstream/2184256;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1042827, chr13-CpG: 18/Downstream/2181392
Nearby gene
SPRY2(-1357186) ;
Nearest cancer related gene
SPRY2(TSG, -1357186) ;
Upstream sequence
ttatgtgcttagaatggggaaatgtgtgattggtctatgggtaggcttggaaaaggaacccttcgattggcttgtggaaaaaaccaattgggagaaagta
Downstream sequence
tgcatatgcaatatagtcttggaaaaggcaccattccattagttacaaggcatcattcagaaagaaccaatagagagacagtgggcaaaatgggaatgga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate