Basic Information
VIS ID
TVIS10010151
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
48164749/47695546 (Hg38)
End
48164749/47695546 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/10743155; hsa-mir-1185-1/Downstream/65449;
Nearest TSS
ENST00000550708/Upstream/20592; ENST00000557531/Downstream/94397;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/19160, chr14-CpG: 30/Downstream/1890386
Nearby gene
MDGA2(-20592) ; MIR548Y(+65449) ;
Upstream sequence
catatggcttataatgaccgttatttttaatcttaATTTTTAAACTACCAAAAGAATTTGCACTCAGAAACAATGACTTCCAGCATGCAGAATTGAAAAT
Downstream sequence
TACCTGTCTTCTTTATTTTGCAGATAGTGTATAATTGCCATTTATTTTTCTAATTTAGCAAACATTTAAAATATATGCATTTCTTAAAATTATTTGGCTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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