Basic Information
VIS ID
TVIS10010152
Fusion event
HBV-LOC105378178 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
49689981/49223263 (Hg38)
End
49689981/49223263 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105378178
Nearest miRNA
hsa-mir-208a/Upstream/1462159; hsa-mir-1185-1/Downstream/743136;
Nearest TSS
ENST00000550708/Upstream/145758; ENST00000557531/Downstream/363062;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1546877, chr14-CpG: 30/Downstream/362669
Nearby gene
LINC00648(-1425764) ; RPS29(+354061) ;
Upstream sequence
AGAATGACACAGTAGTTTCCTGGAAACACCTCACTTGTTTTATTATTCAAATTTTATTCTAATACATTGTCTTGTTTGAAAAATTACCCCCCAGAAAAAC
Downstream sequence
TCTGAAAGgcctgtaatcccagcacttcgggaggccgaggtgggcagatgacctgaggtcaggagatcaagaccagcctggcaaacatggtgaaacccca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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