Basic Information
VIS ID
TVIS10010156
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2281
Orient
+
Integrated sequence
GGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTC| |GCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAAC
Host Sequence
Chromosome
chr14
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
85074711/84608367 (Hg38)
End
85074711/84608367 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1260a/Upstream/7342077; hsa-mir-1185-1/Downstream/9339859;
Nearest TSS
ENST00000550708/Upstream/693317; ENST00000554753/Downstream/631107;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/3074277, chr14-CpG: 45/Downstream/921783
Nearby gene
FLRT2(+921777) ;
Upstream sequence
ttctttcctgtgtctcttcttgatctcagcaagtttccatttaaaacattcttcttcctggagattctcagcaaccttcaggctgccacatctaaaagcc
Downstream sequence
aatttttatcatcatgtttcctctatttgcagcattcaatatagagacctactttctacttctttggccacattctctcttacatttaaagacagtgtat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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