Basic Information
VIS ID
TVIS10010158
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1823
Orient
-
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA
Host Sequence
Chromosome
chr15
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
28603747/28358601 (Hg38)
End
28603747/28358601 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1268a/Upstream/2509776; hsa-mir-10393/Downstream/67890;
Nearest TSS
ENST00000557528/Upstream/36449; ENST00000565126/Downstream/20020;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/36052, chr15-CpG: 62/Downstream/44262
Nearby gene
HERC2(-36449) ; GOLGA8F(+20037) ;
Upstream sequence
AAGAAACATGTCTAATATCTTTAAAAATACAAAGCTTTGAgccaggcatgatggctcatgcctgtaatcccagcactttgggaggctggggcgggtggat
Downstream sequence
cacccgaattcaggagttcaagaccagcctggccaacatgatgaaatcctgtctctactaaaaatacaaaagtagctgggcatggtggcaggtgcctgta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate