Basic Information
VIS ID
TVIS10010160
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1867
Orient
+
Integrated sequence
CTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTC| |AAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGA
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
92805134/92261904 (Hg38)
End
92805134/92261904 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/2255063; hsa-mir-1302-10/Downstream/642495;
Nearest TSS
ENST00000557528/Upstream/89468; ENST00000556382/Downstream/69133;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/345456, chr15-CpG: 170/Downstream/131543
Nearby gene
SLCO3A1(-89469) ; ST8SIA2(+132006) ;
Upstream sequence
cttcggggaggagggataagggatggggagttaagagcacagagtttcagttttgtaaaattaagagttctgatgattggccgtacagaagtgtaaatgt
Downstream sequence
acttaacaccattaaactgcatgattagaaattgttctgatggtaaattttaaattatgcatatcttaccaccatttaataataataataataataataa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate