Basic Information
VIS ID
TVIS10010163
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1991
Orient
+
Integrated sequence
GGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCT| |TCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGG
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
11133199/11229882 (Hg38)
End
11133199/11229882 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA17A
Nearest miRNA
hsa-mir-1253/Upstream/3042878; hsa-mir-10226/Downstream/852017;
Nearest TSS
ENST00000595228/Upstream/351689; ENST00000577346/Downstream/11381;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/499709, chr17-CpG: 244/Downstream/10288
Nearby gene
PIRT(-391781) ; SHISA6(+11541) ;
Upstream sequence
ATAAATTGGAAAACTAGAACTTCAAGCAAAGGTAAAAAAAAAGGTTCTCAAGTTCTCTAGAAATTCCATTTTCAAGCATCTTTGGGCCAATACTCCCTCC
Downstream sequence
TTTAATTGGTACCTGTCTCTCACACGCCTCACCTCAGTACTGGCTGTGTCTGCCCATGTGGTTATGTAATGTCTTGATCAGGGTACAGGATATCAGGTTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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