Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010166
Fusion event
HBV-CRHR1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2105
Orient
+
Integrated sequence
CAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCT| |AGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTG
Host Sequence
Chromosome
chr17
Cytoband
q21.31
Reference genome
Start
End
43872944/45795578 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-1180/Upstream/320143; hsa-mir-10226/Downstream/1177439;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/10016, chr17-CpG: 320/Downstream/98466
Upstream sequence
gcattcctggcctttacccattaaatgccagtcgcacctcccccttcctgattatagcaaccaagaatatcttcagacatcaccaaacgtcccccgggag
Downstream sequence
gcaaaatggcctccaggtgagaatctctgAGCTGGCTGagttatcctcacttctgttgatgcttcagaatcactggaacgcatttaaaaaacataagggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.