Basic Information
VIS ID
TVIS10010168
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2275
Orient
+
Integrated sequence
AATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGT| |GGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAG
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
14135832/14135833 (Hg38)
End
14135832/14135833 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-3976/Upstream/524633; hsa-mir-1-2/Downstream/694333;
Nearest TSS
ENST00000575820/Upstream/3343; ENST00000579292/Downstream/407313;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/3350, chr18-CpG: 17/Downstream/10562
Nearby gene
ZNF519(-3343) ; ANKRD20A5P(+43264) ;
Upstream sequence
CATCGGAAGGCAGGAGGCCAGTGCTCAGCATCTGAATTTGTGTCCTTGTGGACAATGGGGTGCCTTTTTAGGTCCAAGTCCATTTTCACCAAAGAGGAGG
Downstream sequence
CTGGAGACTCTGAATGGCTCCCAGATTCCATTTATGATACTTTTTGGGGTGGGGTCAGAATGGGTCTGAGTTTCAGTATCTTTGGGGAATTCTGAAAAGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate