VISDB Viral Integration Site DataBase

VIS ID

TVIS10010169

Fusion event

HBV-ROCK1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2185

Orient

+

Integrated sequence

TGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCC| |TAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCAC

Chromosome

chr18

Cytoband

q11.1

Reference genome

Start

End

18592676/21012715 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-146a-5p ; hsa-mir-584-5p ; hsa-mir-124-3p ; hsa-mir-1280 ; hsa-mir-148b-3p ; hsa-mir-335-5p ; hsa-mir-148a-3p ; hsa-mir-135a-5p ; hsa-mir-145-5p ; hsa-mir-340-5p ; hsa-mir-4662a-5p ; hsa-mir-4753-5p ; hsa-mir-6507-5p ; hsa-mir-6768-3p ; hsa-mir-548aw ; hsa-mir-5093 ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3688-3p ; hsa-mir-300 ; hsa-mir-506-3p ; hsa-mir-584-3p ; hsa-mir-126-3p ; hsa-mir-144-5p

Nearest miRNA

hsa-mir-3156-2/Upstream/6182473; hsa-mir-1-2/Downstream/670803;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/5681540, chr18-CpG: 113/Downstream/98264

Nearest cancer related gene

ROCK1(OG, No orient, 0)

Upstream sequence

tttgggtttacactttttgtggtttgctaagcttcttggtagttcatgtcttttgtcagttcaggtcttttgtcaaatttgttgaattttctgtcgtcat

Downstream sequence

ttcttcccacgccctttctcctctcctttagtaattcgagtgacacaaatgttagaattttattgttatagttctacaggtcccagaggctctgtcactt