Basic Information
VIS ID
TVIS10010171
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1959
Orient
-
Integrated sequence
TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG| |CCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATA
Host Sequence
Chromosome
chr18
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
23052395/25472431 (Hg38)
End
23052395/25472431 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/1150685; hsa-mir-122/Downstream/1119036;
Nearest TSS
ENST00000575820/Upstream/120241; ENST00000415576/Downstream/562634;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/122165, chr18-CpG: 122/Downstream/617576
Nearby gene
ZNF521(-120181) ; SS18(+543822) ;
Nearest cancer related gene
SS18(OG, +543822) ;
Upstream sequence
AGAGGCATTTCTGATCTAGATATAATTTAAGAGATGCCCTGTTTTACAACCACAGGTCATAGGTAACTTCTGTAAAGGGTGAATCTCTGTGATTGTTGCT
Downstream sequence
GCTTCAGTGTCGGAGGGTATCATTTTGTGACCATGTCTGGGTGCCCCCCAGTGATTGCCTAGGGTTTCCAGGGCCTGGCTATTACCATATGCTATGGACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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