VISDB Viral Integration Site DataBase

VIS ID

TVIS10010176

Fusion event

HBV-NEDD4L integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

770

Orient

-

Integrated sequence

GGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCT| |GTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTC

Chromosome

chr18

Cytoband

q21.31

Reference genome

Start

End

55957706/58290474 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-24-3p ; hsa-mir-1296-5p ; hsa-mir-423-5p ; hsa-mir-7855-5p ; hsa-mir-6807-5p ; hsa-mir-7843-3p ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-5186 ; hsa-mir-4786-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4257 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6504-3p ; hsa-mir-656-3p ; hsa-mir-5011-5p ; hsa-mir-93-3p ; hsa-mir-30a-5p ; hsa-mir-376c-3p

Nearest miRNA

hsa-mir-1-2/Upstream/2811176; hsa-mir-122/Downstream/160600;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/33638, chr18-CpG: 92/Downstream/380505

Nearest cancer related gene

NEDD4L(TSG, No orient, 0)

Upstream sequence

TTGATTATACTTCACAAATGTAAGGTAAAATAGATGATACTATCTGTCATTTGCTTGATGCTATTGGCAAATGTGAAGCAGTTACCAGCATAAAAGCTTG

Downstream sequence

GAGGTTACTCCGAATGTATATAAACAACAGTGGCTAGGCTCACAAGTGGGAGAGAGTCTAAAAATAGGTAGGCGATCCCTTATCTCGTTGCATTGAAAAT