Basic Information
VIS ID
TVIS10010178
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1785
Orient
-
Integrated sequence
CAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTG| |TAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCC
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
GRCh37/hg19
Start
29219038/28728131 (Hg38)
End
29219038/28728131 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/8328777; hsa-let-7e/Downstream/6394569;
Nearest TSS
ENST00000633603/Upstream/79828; ENST00000585883/Downstream/141665;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/305, chr19-CpG: 82/Downstream/65275
Nearby gene
LINC00662(-934190) ; LINC00906(+237000) ;
Upstream sequence
ACAGTGTATTTTCAAAGAATGTCAAATGTAGTATTTGTTTTTATTATTGATCAAAGGCAGCTGTAGCTTCCAATaataatggctaacatctaccgagtac
Downstream sequence
tgtgtgcgagacacccttctgcatgctttacctgaattaccttatttaatcttcaaaaaccatcccgtgagagaggaactattattatacccattttaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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