Basic Information
VIS ID
TVIS10010184
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr2
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
158368523/157512011 (Hg38)
End
158368523/157512011 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-128-1/Upstream/6143600; hsa-mir-10b/Downstream/1674824;
Nearest TSS
ENST00000437798/Upstream/23050; ENST00000604340/Downstream/85549;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1075514, chr2-CpG: 31/Downstream/85276
Nearby gene
CYTIP(-67919) ; ACVR1C(+14756) ;
Nearest cancer related gene
ACVR1C(TSG, +14756) ;
Upstream sequence
ggagatgagcaaagtggaaaaaatagtaaggtaataaaattaaaattaattatgttgataattatgttaactataaatggtctgtacactccaatttttt
Downstream sequence
tttatttttctttaagtttcagggatacatgtgcagaatgtgcaggtttgttacataggtatacatgtgccatggtggtttgctgtacctatcaacccat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate