VISDB Viral Integration Site DataBase

VIS ID

TVIS10010186

Fusion event

HBV-PDE1A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1858

Orient

+

Integrated sequence

GTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTC| |CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT

Chromosome

chr2

Cytoband

q32.1

Reference genome

Start

End

183066487/182201760 (Hg38)

Orient

-

Location type

Exonic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-133b ; hsa-mir-133a-3p ; hsa-mir-5587-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-3691-3p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-1264

Nearest miRNA

hsa-mir-10b/Upstream/896108; hsa-mir-1244-1/Downstream/2177215;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/308968, chr2-CpG: 53/Downstream/514206

Upstream sequence

aaacaacaaaaaaaacacaaaacctacccttcaggctgctgcaaactgtttcttatatttttaatttgctggaAGTGACCTGACATGTCTGTAGATAAAA

Downstream sequence

CCATTTCAATCACTAGGTTCCGAAGATCCCTGCAGAGTCACCAAAAGGAGAAAGGTTCATTCAGCCATTTATTGTTCTGAAGTGGAACACTTCAATAAAT