Basic Information
VIS ID
TVIS10010192
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1787
Orient
-
Integrated sequence
ACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTA| |GGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTT
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
217431610/216566887 (Hg38)
End
217431610/216566887 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC101928180 ; LOC105373871
Nearest miRNA
hsa-mir-10b/Upstream/2808728; hsa-mir-1244-1/Downstream/1333626;
Nearest TSS
ENST00000437798/Upstream/37862; ENST00000441803/Downstream/37884;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/67784, chr2-CpG: 101/Downstream/66163
Nearby gene
RPL37A(-65422) ; IGFBP2(+66517) ;
Upstream sequence
gcgcctgtagtcccagctactcgggaggctgaggcaggaggatggcgtgaatccgggaggcggagtttgcagtgagctgagatcgcgccactgcactcca
Downstream sequence
gcctgggcgacagagcgagactccgtctcaaaaacaaaacaaaacaaaacaaaacagaaaacaaaaaagtctgcagacgcaacaaacaacaggattagac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate