Basic Information
VIS ID
TVIS10010194
Fusion event
HBV-LOC107985988 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2011
Orient
+
Integrated sequence
GACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTC| |TGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTAC
Host Sequence
Chromosome
chr2
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
221752497/220887777 (Hg38)
End
221752497/220887777 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107985988
Nearest miRNA
hsa-mir-10b/Upstream/981212; hsa-mir-1244-1/Downstream/4122684;
Nearest TSS
ENST00000437798/Upstream/96699; ENST00000609776/Downstream/537763;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1259712, chr2-CpG: 260/Downstream/683233
Nearby gene
MIR4268(-981211) ; EPHA4(+530250) ;
Upstream sequence
GTGACTGGGGAGATGAGTAGCTATGGCTTCTCTCTAACTGTGGTTTTGTGCGTCTTTGTGTATGAGCAACAGAGGGCAGTGAAATGGGCGGAGGGATAAA
Downstream sequence
AATAACCAGTCCTTTTATGTTTGGATTGAAAAAAATATCTTGCTAATGCAGTTCTACATTTAACAATTTTTCTTAGGTAAGTTAGACATTTAATAGCAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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