Basic Information
VIS ID
TVIS10010195
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1695
Orient
-
Integrated sequence
CCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGA| |CCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAA
Host Sequence
Chromosome
chr2
Cytoband
q36.3
Reference genome
GRCh37/hg19
Start
227537329/226672613 (Hg38)
End
227537329/226672613 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Upstream/13820; hsa-mir-1244-1/Downstream/799519;
Nearest TSS
ENST00000437798/Upstream/487242; ENST00000607970/Downstream/122633;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1089598, chr2-CpG: 74/Downstream/118574
Nearby gene
MIR5702(-13820) ; IRS1(+58704) ;
Upstream sequence
ggatcccttgaacccagaaggtcaaggctataatgagatttggttgcaccattgcactccagccttggtgatagagggagaccctgtctcgaaaaaGATG
Downstream sequence
CAAGTCTACAACGGAACAGAGGATTAAAATGATATTTAACCTGTGAATTCAAAACTTCTACTTCCCATTTTAATTTGTAAGGGCTTAGGAGGAGGAGGAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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