Basic Information
VIS ID
TVIS10010196
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1849
Orient
+
Integrated sequence
GGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTT| |GTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACT
Host Sequence
Chromosome
chr2
Cytoband
q36.3
Reference genome
GRCh37/hg19
Start
227537684/226672968 (Hg38)
End
227537684/226672968 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Upstream/14175; hsa-mir-1244-1/Downstream/799164;
Nearest TSS
ENST00000437798/Upstream/487597; ENST00000607970/Downstream/122278;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1089953, chr2-CpG: 74/Downstream/118219
Nearby gene
MIR5702(-14175) ; IRS1(+58349) ;
Upstream sequence
TAACCCAATGTCATCATCACACAAATGACTGATGAATGCATTCAGTTATACTCAAGAGCCTTGGTGGAATAACTAATTTTACTCACTAAACAATGCCTAA
Downstream sequence
ATTAACTCAAATATGGAAGAAAAACTTTAGAGGTCAGAAAACTATTGCATATGTATATTTTCTGACTCCTGATATTTGCATATATATTTATttcttccat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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