Basic Information
VIS ID
TVIS10010200
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1999
Orient
+
Integrated sequence
GGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATA| |CCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAAT
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
43201918/42974778 (Hg38)
End
43201918/42974778 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1301/Upstream/7503292; hsa-mir-10b/Downstream/4402897;
Nearest TSS
ENST00000437798/Upstream/182185; ENST00000623515/Downstream/31282;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/146620, chr2-CpG: 50/Downstream/93296
Nearby gene
HAAO(-182167) ; ZFP36L2(+247623) ;
Nearest cancer related gene
ZFP36L2(TSG, +247623) ;
Upstream sequence
AGACAGCAGTAACCCAGGCTATGCATGCAAAAAGTAGGGATAGGAAGAGGTGAAAAAGTTCCAGAAGTCTTTGGAAGGCCTGGCAGCCTCCAGTCATGCC
Downstream sequence
TACAGGCTGAACCCAGCCCAGCTCATCTCAGATAAAGCATCTAATTCAAGTCCTACACGGAGCCCAGGCCTCTGCTCTGAAAAGTCTCTTGACCCCAGCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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