Basic Information
VIS ID
TVIS10010201
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2142
Orient
+
Integrated sequence
TTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCG| |TCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAA
Host Sequence
Chromosome
chr2
Cytoband
p15
Reference genome
GRCh37/hg19
Start
62091819/61864684 (Hg38)
End
62091819/61864684 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1301/Upstream/1477239; hsa-mir-10b/Downstream/341142;
Nearest TSS
ENST00000437798/Upstream/10541; ENST00000425779/Downstream/3748;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/10456, chr2-CpG: 65/Downstream/23626
Nearby gene
FAM161A(-10541) ; CCT4(+3443) ;
Upstream sequence
gtattacagtattttggttatggggcatcaagaagagtaaaacttcactcagtgactttaactcttcttctgaggaaggggttagtgtgtttttggtcct
Downstream sequence
acacaggatagttgtatcatgtcagctggatttatgaccatgttattaccttatttgacggtttaagtatggtttaagatgtatggccgggcgcggtggc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate