Basic Information
VIS ID
TVIS10010203
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1796
Orient
-
Integrated sequence
CTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAAT| |TGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTT
Host Sequence
Chromosome
chr20
Cytoband
q12
Reference genome
GRCh37/hg19
Start
38261425/39632783 (Hg38)
End
38261425/39632783 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/1116151; hsa-mir-1-1/Downstream/1536240;
Nearest TSS
ENST00000382410/Upstream/408035; ENST00000444436/Downstream/152938;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/582325, chr20-CpG: 92/Downstream/1049955
Nearby gene
LINC01734(-408034) ; MAFB(+1053092) ;
Nearest cancer related gene
MAFB(OG, +1053092) ;
Upstream sequence
CTTGGAACAAAATGTCCAGAAGTCCTAGGACACTGGTATCCttgtgttcagggttagtatccacagtacaagtggcacagagaaactgaaatctccaaag
Downstream sequence
gcaggttactggagaagaaaagaaatgctaagccataacacacatgagaaaatcttggaggaatcaggatggctccttctggagatctttaccagctaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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