Basic Information
VIS ID
TVIS10010206
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1801
Orient
-
Integrated sequence
GGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTC| |TGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGG
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
7499200/7518553 (Hg38)
End
7499200/7518553 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/146861; hsa-mir-1-1/Downstream/3131083;
Nearest TSS
ENST00000382410/Upstream/171086; ENST00000607924/Downstream/421921;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/748243, chr20-CpG: 96/Downstream/500589
Nearby gene
BMP2(-738290) ; HAO1(+364431) ;
Nearest cancer related gene
BMP2(TSG, -738290) ;
Upstream sequence
GCACCAAAGACGAATCAGAACAATGTGTATGAGTCTTTATGACTGTTAAATTTTACTGTTACAGAGATGAGAGCTACAGATAAATGATTGATCCATCCCA
Downstream sequence
AAGTAAGTGTGTGTTCAGAGGGCATATAATAGTTTTTAAAGGttattgtggcaaaatatgtataatggaaaatatgccattatatccatctttcagtgta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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