Basic Information
VIS ID
TVIS10010207
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr21
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
15394917/14022596 (Hg38)
End
15394917/14022596 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10396a/Upstream/298322; hsa-let-7c/Downstream/2516493;
Nearest TSS
ENST00000624081/Upstream/252664; ENST00000448463/Downstream/4825;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/11104, chr21-CpG: 20/Downstream/5020
Nearby gene
ANKRD20A11P(-42152) ; LIPI(+86218) ;
Upstream sequence
CAGACTTTTCAGAATTCCCCAAAGATACTGAAACTCAGACCCATTCTGACCCCACCCCAAAAAGTATCATAAATGGAATCTGGGAGCCATTCAGAGTCTC
Downstream sequence
CAGCCTCCTCTTTGGTGAAAATGGACTTGGACCTAAAAAGGCACCCCACTGTCCACAAGGACACAAATTCAGATGCTGAGCACTGGCCTCCTGCCTTCCG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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