Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010209
Fusion event
HBV-CLTCL1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2341
Orient
+
Integrated sequence
ACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTA| |CTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGA
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
Start
End
19193408/19205898 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-3198-1/Upstream/1224937; hsa-let-7a-3/Downstream/757855;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/26595, chr22-CpG: 62/Downstream/85250
Upstream sequence
ATTTTTAAAAAATTTTAAGGAAAAGCTCAATTTTTACCTTTAATTCTTTCATCTGGAATTTTACTTGGTTACAGAATTACATGATGAACTTTTAACACCT
Downstream sequence
TTCAAAACTTTAACTTAATTTCCAACCAttgttttttttttttttgacacaggcttctcactccgtcacccaggttggagtgcagtggcacaatcacagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.