Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010220
Fusion event
HBV-TNIK integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|
Start
1784
Orient
-
Integrated sequence
TCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCT| |GTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGC
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
End
170875995/171158206 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7g/Upstream/51447; hsa-mir-1224/Downstream/4211334;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/129703, chr3-CpG: 89/Downstream/301834
Upstream sequence
gatacagggctggtgagccctaaagtggagcttagcccatgagggttcttggctttgcccaggaaagaattcaagggcaagccagaagtagaagaaaaca
Downstream sequence
gatctgagcccaagcctgctgagtccaagtcagggtttgcctgactgtaccacactTAAAGGGCTTGGTTTGGCTCTGGCCACAGCAGGTGCAGCTAGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.