VISDB Viral Integration Site DataBase

VIS ID

TVIS10010221

Fusion event

HBV-NKTR integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|

Start

1857

Orient

+

Integrated sequence

GGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGT| |CCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTT

Chromosome

chr3

Cytoband

p22.1

Reference genome

Start

End

42687885/42646393 (Hg38)

Orient

-

Location type

UTR3

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-4704-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-497-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-2681-5p

Nearest miRNA

hsa-mir-12127/Upstream/3508127; hsa-let-7g/Downstream/1467819;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/45280, chr3-CpG: 113/Downstream/7643

Upstream sequence

tctgaaattgaagcataattaataacctaccaacaaaaaaagcccaggaccagagagattcacagctgaattctaccagaggtacaaagaggagctggta

Downstream sequence

TTATATACTGATTACATAGAGTCTTGTACATATGTGCTCTAAAAACAAACCACCCAGAATTGATACTGTTGGTAACCAGGAGTATAAGGCAGTGGCTCTG