Basic Information
VIS ID
TVIS10010225
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr4
Cytoband
q28.2
Reference genome
GRCh37/hg19
Start
130399204/129478049 (Hg38)
End
130399204/129478049 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/3970742; hsa-mir-1305/Downstream/13865411;
Nearest TSS
ENST00000502981/Upstream/173027; ENST00000508724/Downstream/293429;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/384305, chr4-CpG: 27/Downstream/2245143
Nearby gene
C4orf33(-365361) ;
Upstream sequence
atatctacccaaagggaaataagtcattacatcaaaaagacacctacatgcatctgtttattgcagcacaatttcaaagatatggaaccaatctaagtac
Downstream sequence
atctattgaaatccagatgcactatgttataagaatttttctgacctttgagaatggcaagctaacaaataagataaaataaaataaatcaaacacgtct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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