Basic Information
VIS ID
TVIS10010228
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1810
Orient
-
Integrated sequence
CAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCA| |GCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACAT
Host Sequence
Chromosome
chr4
Cytoband
q31.23
Reference genome
GRCh37/hg19
Start
150887892/149966740 (Hg38)
End
150887892/149966740 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/2184072; hsa-mir-1305/Downstream/2522587;
Nearest TSS
ENST00000502981/Upstream/10532; ENST00000507694/Downstream/111534;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1520836, chr4-CpG: 161/Downstream/111358
Nearby gene
NR3C2(-1524220) ; DCLK2(+111534) ;
Upstream sequence
accagaaggattcacagccaaattctaccagaggtacaaagaggagctggtaccatttcttctgaaactattccaaacaatagaaaaagaggatctggta
Downstream sequence
AGGAGCTCCCAATGAATCTAGATCTTAAAATATTTCAGCAGTTGAGGAATAGAGAAGAAAACAAGGAAGATACTTCAGGTGAAGTAAAACACATGACTCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate