Basic Information
VIS ID
TVIS10010232
Fusion event
HBV-LOC102723733 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1830
Orient
+
Integrated sequence
ACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCAC| |CTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTG
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
25872724/25871102 (Hg38)
End
25872724/25871102 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LOC102723733
Nearest miRNA
hsa-mir-12113/Upstream/1350812; hsa-mir-1243/Downstream/2948480;
Nearest TSS
ENST00000502981/Upstream/1552; ENST00000522137/Downstream/42804;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/7348, chr4-CpG: 61/Downstream/42628
Nearby gene
SEL1L3(-8114) ; SMIM20(+43090) ;
Upstream sequence
cattccattccattccattccattccattccattccattccattccattccattctatttcattccattccactccattccattccattcctctctggtt
Downstream sequence
AGAAACCATGTCTGTCTTCTGCGTAGTGTGGTGTTTATGCATTACTGGTGCTTATTAAAGCTTTTTTTCATTAACAGCACCTTCACAGTCTGATAATAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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