Basic Information
VIS ID
TVIS10010236
Fusion event
HBV-ADGRL3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2053
Orient
+
Integrated sequence
TTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTC| |ACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCT
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
62085873/61220155 (Hg38)
End
62085873/61220155 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADGRL3
miRNAs that regulate target gene
hsa-mir-20a-5p
Nearest miRNA
hsa-mir-12113/Upstream/297471; hsa-mir-1243/Downstream/5056669;
Nearest TSS
ENST00000502981/Upstream/18013; ENST00000509089/Downstream/208066;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/17072, chr4-CpG: 60/Downstream/2128974
Nearby gene
LPHN3(+276966) ;
Upstream sequence
tcctttccatttcattccattccattcctttcctctcgggttgattccattccattcctttccattctgttccattccattccgttccattccattccat
Downstream sequence
TCCATGGCTGGAACTTCTTTTAGTCTTTTCATAAGCTAGAGTATTTGGTTATGAAAATGAGATTTGATTTTTTTCGAAGGTAGGGGCTTAGTATATTAGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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