Basic Information
VIS ID
TVIS10010238
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1829
Orient
+
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr5
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
101423131/102087427 (Hg38)
End
101423131/102087427 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5F
Nearest miRNA
hsa-mir-10397/Upstream/1270862; hsa-mir-103a-1/Downstream/8426402;
Nearest TSS
ENST00000502646/Upstream/1184161; ENST00000506058/Downstream/56650;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1183993, chr5-CpG: 26/Downstream/209019
Nearby gene
ST8SIA4(-1184144) ; SLCO4C1(+146561) ;
Upstream sequence
CCGCCCGCACAGGGTGGAGGGCAACCTCGGGGTCCAGGCACCTGGCTCCAAGCCTCGGACTGCAGAGCTAGGAGGCCCGACTTCCAGCCCAGCAGTAGAA
Downstream sequence
TGGTAAAAACAAAACAAAAGAAAACACAGAAGTAATTTTGGCTTATTTTACAACTGAGACATCAACTCACTCCAAAAATTGAGTCTTCTTTAAAACATCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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