Basic Information
VIS ID
TVIS10010241
Fusion event
HBV-LOC105379110 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2358
Orient
+
Integrated sequence
GGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGA| |GGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATT
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
104668374/105332673 (Hg38)
End
104668374/105332673 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5F
Target gene
LOC105379110
Nearest miRNA
hsa-mir-10397/Upstream/4516108; hsa-mir-103a-1/Downstream/5181156;
Nearest TSS
ENST00000502646/Upstream/86309; ENST00000513676/Downstream/60297;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2072824, chr5-CpG: 253/Downstream/2336756
Nearby gene
RAB9BP1(-232575) ;
Upstream sequence
ccaggttttggtatcaggatgatgctggcctcataaaatgagttaaggaggagtccccctcttttcctattgtttggaatagtttcagaagaaatggttc
Downstream sequence
GCAAAGCTGCTCCTATTCAATCTAGAAATAAGAGAAACATATAGTGAAAAATCATCAAGGAACTGGAAATCTGAGCATCAATGTAAGCTTTTTAGTTACT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate