VISDB Viral Integration Site DataBase

VIS ID

TVIS10010242

Fusion event

HBV-PGGT1B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1834

Orient

+

Integrated sequence

GGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCT| |GCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGC

Chromosome

chr5

Cytoband

q22.3

Reference genome

Start

End

114562601/115226904 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-591 ; hsa-mir-582-3p ; hsa-mir-582-5p ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-4795-5p ; hsa-mir-4282 ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-487b-5p ; hsa-mir-487a-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-3614-5p ; hsa-mir-942-3p ; hsa-mir-4802-3p ; hsa-mir-1276

Nearest miRNA

hsa-mir-10397/Upstream/4712989; hsa-mir-103a-1/Downstream/1028839;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/46381, chr5-CpG: 35/Downstream/35700

Upstream sequence

gaaactgaggcagtaattaatagcctaccaacaaaaacaaaagcccaagaccagacggagtcacagcctaattctaccagaggtacaaagagcagctgga

Downstream sequence

gatagattaaactctgacggttatgaaaagagaaacaagcagaagcaagtggaaaggaagcatttcaagcaaaggaaaaggaatattagcaacgtccaga