Basic Information
VIS ID
TVIS10010243
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1820
Orient
-
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr5
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
169055648/169628644 (Hg38)
End
169055648/169628644 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5G
Nearest miRNA
hsa-mir-10397/Upstream/364950; hsa-mir-10523/Downstream/399844;
Nearest TSS
ENST00000502646/Upstream/33370; ENST00000522138/Downstream/8603;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/44473, chr5-CpG: 46/Downstream/8622
Nearby gene
SPDL1(-23867) ; DOCK2(+8603) ;
Upstream sequence
catggtgaaaccctgtctctacaaaaagtacaaaaattagccaggcatggtggcatgtgcctgtagttccagctatttgggaggctgaggcaggaggact
Downstream sequence
tatagtagactgttttctattcctttgggtatgtacctagtaatgggattgctgggtcaaatggtatttctggttctagatccttgcgaggctgtgaaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate