Basic Information
VIS ID
TVIS10010247
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1906
Orient
-
Integrated sequence
ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG| |ACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTC
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
106806766/106358891 (Hg38)
End
106806766/106358891 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6F
Nearest miRNA
hsa-mir-10398/Upstream/7234195; hsa-mir-1202/Downstream/425234;
Nearest TSS
ENST00000381078/Upstream/33100; ENST00000487681/Downstream/826;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/32963, chr6-CpG: 91/Downstream/1518
Nearby gene
ATG5(-33071) ; SLC45A2(+152964) ;
Upstream sequence
taatGTTTAATGTAATTACCTTATAATCATATTTACTATTATAAACTAGTCTAGTATAAAAATCATGTAATCaaaatattaaaatatttttaaGAACCAC
Downstream sequence
gctgctcaggaggctgaggtgggacgatcacttgtgctcaggtggtcaaggctgcagtgagtgcagtgagaggtgatggtaacagtgtactcctacctga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate