Basic Information
VIS ID
TVIS10010249
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1706
Orient
-
Integrated sequence
CGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCAT| |ACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGC
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
113772022/113450820 (Hg38)
End
113772022/113450820 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA6F
Nearest miRNA
hsa-mir-10398/Upstream/6666600; hsa-mir-1202/Downstream/5618227;
Nearest TSS
ENST00000381078/Upstream/17399; ENST00000415883/Downstream/80298;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1083292, chr6-CpG: 205/Downstream/407738
Nearby gene
RFPL4B(-1099524) ; MARCKS(+406505) ;
Nearest cancer related gene
MARCKS(TSG, +406505) ;
Upstream sequence
atatttaatgtgtacaatttgacatatttggacatatacatatacccataaaaccattacaacaatcgagataatgagtacatcacccccagtagattct
Downstream sequence
ATATGTCCCCTGCTACTTATATTCCTAACTGGAAGGGCTTTTGTTAGTGTTACCCTTTGAGTTGGTTCTcagggctgggggtagggtgaggtaagtgaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate