Basic Information
VIS ID
TVIS10010250
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1997
Orient
+
Integrated sequence
GGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGA| |TACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTA
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
118162153/117840990 (Hg38)
End
118162153/117840990 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/11056770; hsa-mir-1202/Downstream/1228057;
Nearest TSS
ENST00000381078/Upstream/165488; ENST00000360388/Downstream/66536;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/164778, chr6-CpG: 166/Downstream/65889
Nearby gene
NUS1(-130267) ; SLC35F1(+66536) ;
Upstream sequence
tcccttgtgcaataggtttctggacttcttattgggtctcattggcatcttgcatattcttgggccgtcatctcactttcttaTTATACGCAGGAGACTA
Downstream sequence
agctccagtaatgcaccctaaggaaataaataatagttgaaatctaaaaaatagaataaaattacagtatttgctactcaaaaaaagaaggaaaaagaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate