Basic Information
VIS ID
TVIS10010252
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2355
Orient
+
Integrated sequence
TTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGA| |CGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGT
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
122680819/122359674 (Hg38)
End
122680819/122359674 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/2344417; hsa-mir-1202/Downstream/4124957;
Nearest TSS
ENST00000381078/Upstream/923982; ENST00000465214/Downstream/39872;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1024798, chr6-CpG: 95/Downstream/39788
Nearby gene
GJA1(-909946) ; HSF2(+39877) ;
Nearest cancer related gene
GJA1(TSG, -909946) ;
Upstream sequence
tctgaaattgaggcagtaattaacaacctaccaaccaaaaaacccaggaccggacggattcacagccgaattctaccagatgtacaaagaggagctgcta
Downstream sequence
CTTCCTCTCCTCATATCTAATTACTAACCTGTGCCTGTCAATTTTTCTTTGAAATTTCCCCTTATCTCAATCCCTGTCTTCTACTACTACCTGGCCAGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate