Basic Information
VIS ID
TVIS10010253
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr6
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
129050068/128728923 (Hg38)
End
129050068/128728923 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/2244210; hsa-mir-1202/Downstream/3063249;
Nearest TSS
ENST00000381078/Upstream/208249; ENST00000466230/Downstream/154218;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/148143, chr6-CpG: 29/Downstream/201045
Nearby gene
PTPRK(-208198) ; LAMA2(+154218) ;
Nearest cancer related gene
PTPRK(TSG, -208198) ;
Upstream sequence
cccacacattaataatgggagactttaataccccactgtcaacattagacagatcagtgagacagaaagttaacaaggatacccaggaattgaactcagc
Downstream sequence
taggtgtataaatcagtggcataaagtactttcacattgttgtgcaTTGAATCCACTTTAAACCGAAGTCTTTCTTCTTCTAGGCTATGAGCACACTGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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