Basic Information
VIS ID
TVIS10010255
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1708
Orient
-
Integrated sequence
CATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATAC| |TTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCAC
Host Sequence
Chromosome
chr6
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
140689615/140368478 (Hg38)
End
140689615/140368478 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/163152; hsa-mir-1202/Downstream/315336;
Nearest TSS
ENST00000381078/Upstream/281796; ENST00000565399/Downstream/484446;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/993037, chr6-CpG: 46/Downstream/1719858
Nearby gene
MIR3668(-163152) ; MIR4465(+315336) ;
Upstream sequence
GGTAGCTGGAGTGGGATTGGGGTTGAGAGAAAGTTTTGGGGTTTTTTTGTTTTGTTTTTTCAAGTTACCAGGTAATTGAGGAtttttttttttagatgga
Downstream sequence
gcagcctgggtccccacatgagtaaattgaaactcaattcaatgtaaataacatcctagaaaaatgaaacttaagctttaccaatcagaaactgccaact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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