Basic Information
VIS ID
TVIS10010257
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2810
Orient
+
Integrated sequence
GAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCAT| |TTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATC
Host Sequence
Chromosome
chr6
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
159794385/159373353 (Hg38)
End
159794385/159373353 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/608600; hsa-mir-1913/Downstream/7136001;
Nearest TSS
ENST00000381078/Upstream/18680; ENST00000429657/Downstream/10178;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/57412, chr6-CpG: 114/Downstream/319172
Nearby gene
FNDC1(-101245) ; SOD2(+305764) ;
Nearest cancer related gene
SOD2(TSG, +305764) ;
Upstream sequence
TAGTGCACAGTGAATTTGTTTTTATAATCATACTGTGCACTATTTCAAGCACCATCCAAAGGAGAAAGGAAAAGATAATGAGAATATACAGCAcatcatc
Downstream sequence
CTATGATTCCAACTGGAAACACTGAAATCTCCAAATTCTTCATTTCAACTGGATTCCAACCAAGTGAAAACACATTGAGAAATTAGGCCTTGCTCTAATC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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